Detection of Hemophilia A Carriers Using Intragenic Factor VHI:C DNA Polymorphisms
نویسنده
چکیده
A DNA polymorphism for an Xbal site in intron 22 of the human factor VIlI:C gene extends the utility of DNA methods for carrier detection in families segregating for hemophilia A. While the DNA polymorphism detected by a BcII site in intron 1 8 of the factor Vlll:C gene was informative for 41 % of females studied, the BgIl/intron 25 polymerphism provided no additional information because of apparent linkage disequilibrium. In contrast, the XbaI intron 22 polymorphism was useful in 53% of women who were
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